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No. 461
Yes, you can do this. No its not that hard.
The most difficult part is finding a case molding that will fit whatever motherboard you want -- as almost all tablet/notebook motherboards are designed to deliberately not play well with case designs other than their own company's. That said, you may get away with using slimline server motherboards (lots of slim/single-nut server mobos are actually vanilla laptop mainboard form factors) and an E450 (or E350 -- both of these are usually built directly into the board, not separate chips) or maybe something low-wattage and Llano.
If you're not wise to the low-wattage arena, you may be surprised at me recommending AMD there, but the fact is in the low-wattage category there is no alternative unless you simply don't want 3D graphics at all -- Intel's integrated graphics blow and nVidia drinks lithium. But if you're willing to build a granite slab instead of a tablet, then whatever.
Screens are buyable, but a bit pricey unless you're buying bulk. Toshiba sells replacements to their tablets as separate items (and they cost more than a new tablet from them anyway, so...). The touchscreen and graphics connections are all standard stuff, so its not that crazy of an idea.
But unless its just a for-fun/learning project, I'd just buy an x86-based tablet and be done with it -- it'll save you money, time and headbanging -- though it'd earn you some street cred with fledgling hardware modders. Anyway, the case is going to be the hardest part, and may require contacting a custom plastics fabricator (not impossible, or even hard, just stuff that takes a little money and most folks don't know much about).
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