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No. 1046
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there are a few.
MDMA works as a serotonin agonist, causing your brain to be flooded with that particular neurotransmitter. Just as a body becomes habituated to any routine chemical use, frequent enough usage will mean that 1) serotonin levels are low to begin with and 2) without the X, the neurons will tend to horde their share of serotonin, releasing it only under greater than normal simulation.
This has a wide variety of effects throughout the body, but the greatest is a lack of joy, and even depression.
Body wise there can be some effects as well; early prostatic hypertrophy, mineral depletion in the body, tremor (which may be permanent).
The ONDCP would have one believe that it leads to holes in the brain, but this is only in rats they had swimming in the stuff. The labwork is considered extremely flawed, by anyone who has looked into it and hasn't taken the governments money.
Any specific questions?
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